Isabel Pires

Hon Secretary

Work in the Pires laboratory at the University of Manchester focuses on the continued evaluation of hypoxia biology both in the context of improved therapeutic outcomes and of novel biomarker value. We are particularly interested in exploring hypoxic biology therapeutically in the context of radiotherapy resistance, as well as novel radio sensitising strategies. Finally, we are looking at the impact of interstitial fluid flow (IFF) in tumour biology, particularly its interaction with hypoxic biology, using our ‘spheroid-on-chip’ microfluidic model.

Isabel did her PhD at the University of Manchester/CRUK Manchester Institute with Professor Caroline Dive. She then moved to the University of Oxford for a postdoc in Professor Ester Hammond's group at the Department of Oncology. There she became interested in how hypoxic biology leads to alterations in cellular behaviour, such as increased genomic instability, resistance to therapy, and increased metastatic potential. She then moved to the University of Hull to start her 1st independent position (lecturer and later senior lecturer), where she continued her interest in hypoxic biology and radiobiology. She has recently (March 2023) moved back to Manchester (Division of Cancer Sciences/MCRC).

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