J Martin Brown

Honorary Member 2015

Dr. J. Martin Brown is a professor in the Division of Radiation and Cancer Biology at Stanford University School of Medicine. He received his undergraduate degree in Physics from Birmingham University and his D.Phil from Oxford University in 1968. He has been member of the ARR since 1967. His research focuses on the mechanisms responsible for the resistance of solid tumors to various cancer therapies and the development of new drugs to improve the success rate of radiation therapy and cancer chemotherapy. He is well known for developing the hypoxic cell radiosensitizer etanidazole, and the hypoxic cell cytotoxin (tirapazamine), both of which have undergone phase III clinical testing. His current work is on the effect of bone marrow derived cells on tumor response, particularly monocytes/macrophages and has shown that tumor irradiation produces a influx of tumor associated macrophages, which promote tumor recurrence. In particular he has demonstrated that this influx can be inhibited and this enhances tumor response to radiation. This new strategy is being tested clinically with glioblastoma. 
He has published more than 300 peer reviewed papers and has received a number of awards in recognition of his work, including the 1999 Bruce Cain Memorial Award from the American Association for Cancer Research for outstanding preclinical research in cancer chemotherapy, the 1999 Gold Medal from the American Society for Therapeutic Radiology and Oncology, the Weiss medal from the Association for Radiation Research in 2001, and the Henry S. Kaplan Distinguished Scientist Award, from the International Association of Radiation Research, in 2007. He is currently an associate editor of Anticancer Research, Radiotherapy & Oncology, Neoplasia, Cancer Letters, and Molecular Cancer Therapeutics.

« Back